The main characteristics of the ongoing revolution in life sciences are reconstructed, and the history of epigenetics as an alternative to the dominant paradigm of the last half century, based on the "central dogma of molecular biology", is described. The main research literature linking social and environmental influences on cellular epigenetic modifications is also presented. Conscious and unconscious mental events may produce epigenetic marks, and this is possible because psychoneuroendocrinoimmunology (PNEI) research has found evidence that psychological and biological levels communicate and influence each other. From this revolution, a complex vision of the individual and of vital microsystems emerges, so that both the organism and the genome are non-reductionistically explained and interpreted. A simplified and fragmented vision of the human being can be abandoned, so that we can redirect research and establish new bases for care, integrating psychology and medicine.
Keywords: Epigenetics, psychoneuroendocrinoimmunology (PNEI), reductionism, new biology, unity of knowledge