This article focuses on entrepreneurial practices in some socio-economically fragile territories in Apulia, Calabria, and Sicily (Italy). From the interaction between immigrant and native people, these practices attempt to combine the re-activation of local civic resources by enhancing the skills that migrants achieved in their countries of origin. The analyzed examples - as innovative welfare practices - should be considered solidarity agreements, useful in triggering resilient dynamics relating to forms of relational embeddedness. Thanks to the involvement of local administrations and social actors, these can indicate a possible path to the socio-economic regeneration of the territories and for the promotion of multicultural lifestyles