Promoting adolescent’s health and well-being in school context - Health and well-being have been separated for a long time from other aspects of school life and only recently they have been considered as the main objectives of health promotion educational programmes. Even in Italy, the recommendations by international charters on human health and the stimulation coming mainly from other European countries and the United States have resulted in a flourishing of initiatives on Health Education, involving different type and level schools. This was made possible through a profound political and cultural change, which have initiated for a long time in our country. This change took the interest in the development of child and adolescent as a priority in education and considered these subjects as legitimate holders of the right and duty to health and active players in the process of personal and social growth. Approaching to health and well-being of adolescents in the perspective of Social Psychology and Community Psychology, by addressing issues crossing different realities, categories and social conditions, contributes greatly to develop a more general reflection on the challenges posed by health promotion in the structure of society. This approach has criticized a medical and sectoral vision, and has gradually become more integrated and complex, assuming a bio-psycho-social perspective which deems extremely important the interdependence between different levels of health, between the individual and social components of well-being, among different subjects, between different contexts objectively and subjectively significant in this regard. Key words: health promotion; psycho-social well-being; adolescence; school setting.