The author aims to look at the issue of a new "communication frontier" created by the possibility of having the entire sequence of the human genome. This "frontier" represents a complex communicative context in which the relationship between social actor, media, scientific research and medical risks to become a real battleground between power and languages. Any communication of health implies the need to inform effectively the public and decision-makers who are not necessarily experts, even more generally "non-experts", with a non-trivial language that simplifies the "expert knowledge" in a world characterized oriented toward a complex hyper-specializations .
Keywords: Public Health Genomics, information, expert knowledge, predictive medicine, organization.