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Funzioni cognitive e demenza: stili di vita e invecchiamento attivo
Titolo Rivista: SALUTE E SOCIETÀ 
Autori/Curatori: Antonio Guaita 
Anno di pubblicazione:  2016 Fascicolo: Lingua: Italiano 
Numero pagine:  15 P. 55-69 Dimensione file:  320 KB
DOI:  10.3280/SES2016-001005
Il DOI è il codice a barre della proprietà intellettuale: per saperne di più:  clicca qui   qui 


Dementia is one of the leading cause of disability in the elderly. One of the most intriguing challenge is nowadays maintaining good cognitive function and avoiding dementia in the aging population, but pharmacological intervention has no role in the prevention. It is of primary interest to study modifiable lifestyle factors that can positively influence cognitive functions in the elderly. In this article the concepts of "successful aging" and "cognitive reserve" were examined in relation to the role of education and midlife experiences. An active lifestyle seems beneficial both for cognitive function than for dementia at any age. A large number of observational, convergent longitudinal data confirms that physical as well as mental activities can reduce the cognitive decline and the incidence of dementia. Also working experience and retirement could be possible factors influencing cognitive functions and dementia, giving useful indications for future improvements for older workers.


Keywords: Invecchiamento; demenza; deterioramento cognitivo; attività fisica; attività mentale; riserva cognitiva.

  1. Adam S., Bonsang E., Grotz C., Perelman S. (2013). Occupational activity and cognitive reserve: implications in terms of prevention of cognitive aging and Alzheimer's disease. Clin Interv Aging, 8: 377-90.
  2. Andel R., Crowe M., Hahn E.A., Mortimer J.A., Pedersen N.L., Fratiglioni L., Johansson B., Gatz M. (2012). Work-related stress may increase the risk of vascular dementia. J Am Geriatr Soc, 60: 60-67., 10.1111/j.1532-5415.2011.03777AngevarenM.,AufdemkampeG.,VerhaarH.,AlemanA.,VanheesL.(2008).Physicalactivityandenhancedfitnesstoimprovecognitivefunctioninolderpeoplewithoutknowncognitiveimpairment.CochraneDatabaseofSystematicReviewsDOI:10.1002/14651858.CD005381.pubDOI: 10.1111/j.1532-5415.2011.03777AngevarenM.,AufdemkampeG.,VerhaarH.,AlemanA.,VanheesL.(2008).Physicalactivityandenhancedfitnesstoimprovecognitivefunctioninolderpeoplewithoutknowncognitiveimpairment.CochraneDatabaseofSystematicReviewsDOI:10.1002/14651858.CD005381.pub
  3. Benedict C., Brooks S.J., Kullberg J., Nordenskjöld R., Burgos J., Le Grevès M., Kilander L., Larsson E.M., Johansson L., Ahlström H., Lind L., Schiöth H.B. (2013). Association between physical activity and brain health in older adults. Neurobiol Aging, 34: 83-90., 10.1016/j.neurobiolaging.2012.04.01DOI: 10.1016/j.neurobiolaging.2012.04.01
  4. Bugiani O. (2011). Alzheimer's disease: ageing-related or age-related? New hypotheses from an old debate. Neurol Sci.; 32:1241-7., 10.1007/s10072-011-0614-DOI: 10.1007/s10072-011-0614-
  5. Carlson M.C., Helms M.J., Steffens D.C., Burke J.R., Potter G.G., Plassman B.L. (2008). Midlife activity predicts risk of dementia in older male twin pairs. Alzheimers Dement, 4: 324–31., 10.1016/j.jalz.2008.07.00DOI: 10.1016/j.jalz.2008.07.00
  6. Chertkow H., Massoud F., Nasreddine Z., Belleville S., Joanette Y., Bocti C., Drolet V., Kirk J., Freedman M., Bergman H. (2008). Diagnosis and treatment of dementia: 3. Mild cognitive impairment and cognitive impairment without dementia. CMAJ, 178: 1273–85., 10.1503/cmaj.07079DOI: 10.1503/cmaj.07079
  7. Daffner K.R. (2010). Promoting Successful Cognitive Aging: A Comprehensive Review J Alzheimers Dis, 19: 1101–22., 10.3233/JAD-2010-130DOI: 10.3233/JAD-2010-130
  8. Daffner K.R., Chong H., Riis J., Rentz D.M., Wolk D.A., Budson A.E., Holcomb P.J. (2007). Cognitive status impacts age-related changes in attention to novel and target events in normal adults. Neuropsychology, 21: 291–300., 10.1037/0894-4105.21.3.29DOI: 10.1037/0894-4105.21.3.29
  9. Daffner K.R., Ryan K.K., Williams D.M., Budson A.E., Rentz D.M., Scinto L.F.M., Holcomb P.J. (2005). Age-related differences in novelty and target processing among cognitively high performing adults. Neurobiol Aging, 26:1283-95., 10.1016/j.neurobiolaging.2004.11.00DOI: 10.1016/j.neurobiolaging.2004.11.00
  10. De Ronchi D., Fratiglioni L., Rucci P., Paternicò A., Graziani S., Dalmonte E. (1998). The effect of education on dementia occurrence in an Italian population with middle to high socioeconomic status. Neurology, 50: 1231-38., 10.1212/WNL.50.5.123DOI: 10.1212/WNL.50.5.123
  11. Dufouil C., Pereira E., Chêne G., Glymour M.M., Alpérovitch A., Saubusse E., Risse-Fleury M., Heuls B., Salord J.C., Brieu M.A., Forette F. (2014). Older age at retirement is associated with decreased risk of dementia. Eur J Epidemiol, 29: 353-61., 10.1007/s10654-014-9906-DOI: 10.1007/s10654-014-9906-
  12. Etgen T., Sander D., Huntgeburth U., Poppert H., Förstl H., Bickel H. (2010). Physical activity and incident cognitive impairment in elderly persons: the INVADE study. Arch Intern Med, 170: 186-93., 10.1001/archinternmed.2009.49DOI: 10.1001/archinternmed.2009.49
  13. Finkel D., Andel R., Gatz M., Pedersen N.L. (2009). The role of occupational complexity in trajectories of cognitive aging before and after retirement. Psychol Aging, 24: 563-73., 10.1037/a001551DOI: 10.1037/a001551
  14. FitzGerald D., Keane R.A., Reid A., O'Neill D. (2013). Ageing, cognitive disorders and professional practice. Age Ageing, 42: 608-14., 10.1093/ageing/aft06DOI: 10.1093/ageing/aft06
  15. Fratiglioni L., Paillard-Borg S., Winblad B. (2004). An active and socially integrated lifestyle in late life might protect against dementia. Lancet Neurol, 3: 343-53., 10.1016/S1474-4422(04)00767-DOI: 10.1016/S1474-4422(04)00767-
  16. Fritsch T., McClendon M.J., Smyth K.A., Lerner A.J., Friedland R.P., Larsen J.D. (2007). Cognitive functioning in healthy aging: the role of reserve and lifestyle factors early in life. Gerontologist, 47: 307-22., 10.1093/geront/47.3.30DOI: 10.1093/geront/47.3.30
  17. Garibotto V., Borroni B., Kalbe E., Herholz K., Salmon E., Holtoff V., Sorbi S., Cappa S.F., Padovani A., Fazio F., Perani D. (2008). Education and occupation as proxies for reserve in aMCI converters and AD: FDG-PET evidence. Neurology, 71: 1342-49., 10.1212/01.wnl.0000327670.62378.cDOI: 10.1212/01.wnl.0000327670.62378.c
  18. Rogers R.L., Meyer J.S., Mortel K.F. (1990). After reaching retirement age physical activity sustains cerebral perfusion and cognition. J Am Geriatr Soc, 38: 123-8
  19. Helmer C., Letenneur L., Rouch I., Richard-Harston S., Barberger-Gateau P., Fabrigoule C., Orgogozo J.M., Dartigues J.F. (2001). Occupation during life and risk of dementia in French elderly community residents. J Neurol Neurosurg Psychiatry, 71: 303-09., 10.1136/jnnp.71.3.30DOI: 10.1136/jnnp.71.3.30
  20. Ilmarinen J.E. (2001). Aging workers. Occup Environ Med, 58:546-52., 10.1136/oem.58.8.54DOI: 10.1136/oem.58.8.54
  21. Jack C.R. Jr., Holtzman D.M. (2013). Biomarker modeling of Alzheimer's disease. Neuron, 80: 1347-58., 10.1016/j.neuron.2013.12.00DOI: 10.1016/j.neuron.2013.12.00
  22. Karp A., Andel R., Parker M.G., Wang H.X., Winblad B., Fratiglioni L. (2009). Mentally stimulating activities at work during midlife and dementia risk after age 75: follow-up study from the Kungsholmen Project. Am J Geriatr Psychiatry, 17(3): 227-36., 10.1097/JGP.0b013e318190b69DOI: 10.1097/JGP.0b013e318190b69
  23. Karp A., Kåreholt I., Qiu C., Bellander T., Winblad B., Fratiglioni L. (2004). Relation of education and occupation-based socioeconomic status to incident Alzheimer's disease. Am J Epidemiol, 159: 175-183., 10.1097/JGP.0b013e318190b69DOI: 10.1097/JGP.0b013e318190b69
  24. Katz S., Peters K.R., (2012). Enhancing the mind? Memory medicine, dementia, and the aging brain Salute e Società , XI/2 Supp.: 56-76., 10.3280/SES2012-SU2005EDOI: 10.3280/SES2012-SU2005E
  25. Kimura K., Yasunaga A., Wang L.Q. (2013). Correlation between moderate daily physical activity and neurocognitive variability in healthy elderly people. Arch Gerontol Geriatr, 56: 109-17., 10.1016/j.archger.2012.10.00DOI: 10.1016/j.archger.2012.10.00
  26. Koenen K.C., Moffitt T.E., Roberts A.L., Martin L.T., Kubzansky L., Harrington H.,Poulton R., Caspi A. (2009). Childhood IQ and adult mental disorders: a test of the cognitive reserve hypothesis. Am J Psychiatry, 166:50-7., 10.1176/appi.ajp.2008.0803034DOI: 10.1176/appi.ajp.2008.0803034
  27. Kramer A.F., Hahn S., Cohen N.J., Banich M.T., McAuley E., Harrison C.R., Chason J., Vakil E., Bardell L., Boileau R.A., Colcombe A. (1999). Ageing, fitness and neurocognitive function. Nature, 400: 418-9., 10.1038/2268DOI: 10.1038/2268
  28. Lee S., Kawachi I., Berkman L.F., Grodstein F. (2003). Education, other socioeconomic indicators, and cognitive function. Am J Epidemiol, 157: 712-20., 10.1093/aje/kwg04DOI: 10.1093/aje/kwg04
  29. Marengoni A., Fratiglioni L., Bandinelli S., Ferrucci L. (2011). Socioeconomic status during lifetime and cognitive impairment no-dementia in late life: the population-based aging in the Chianti Area (InCHIANTI) Study. J Alzheimers Dis, 24: 559-68., 10.3233/JAD-2011-10186DOI: 10.3233/JAD-2011-10186
  30. McDermott H.J., Kazi A., Munir F., Haslam C. (2010). Developing occupational health services for active age management. Occup Med, 60: 193-204., 10.1093/occmed/kqq02DOI: 10.1093/occmed/kqq02
  31. Meng X., D'Arcy C. (2012). Education and dementia in the context of the cognitive reserve hypothesis: a systematic review with meta-analyses and qualitative analyses. PLoS One, 7(6):e38268., 10.1371/journal.pone.003826DOI: 10.1371/journal.pone.003826
  32. Middleton L.E., Manini T.M., Simonsick E.M., Harris T.B., Barnes D.E., Tylavsky F., Brach J.S., Everhart J.E., Yaffe K. (2011). Activity energy expenditure and incident cognitive impairment in older adults. Arch Intern Med, 25, 171: 1251-7., 10.1001/archinternmed.2011.27DOI: 10.1001/archinternmed.2011.27
  33. Potter G.G., Helms M.J., Plassman B.L. (2008). Associations of job demands and intelligence with cognitive performance among men in late life. Neurology, 70:1803-08., 10.1212/01.wnl.0000295506.58497.7ePrinceM.,BryceR.,AlbaneseE.,WimoA.,RibeiroW.,FerriC.P.(2013).Theglobalprevalenceofdementia:asystematicreviewandmetaanalysis.AlzheimersDement;9:63-75.e2.DOI:10.1016/j.jalz.2012.11.00DOI: 10.1212/01.wnl.0000295506.58497.7ePrinceM.,BryceR.,AlbaneseE.,WimoA.,RibeiroW.,FerriC.P.(2013).Theglobalprevalenceofdementia:asystematicreviewandmetaanalysis.AlzheimersDement;9:63-75.e2.DOI:10.1016/j.jalz.2012.11.00
  34. Ravaglia G., Forti P., Maioli F., Sacchetti L., Mariani E., Nativio V., Talerico T., Vettori C., Macini P.L. (2002). Education, occupation, and prevalence of dementia: findingsfrom the Conselice study. Dement Geriatr Cogn Disord, 14:90-100., 10.1159/00006493DOI: 10.1159/00006493
  35. Rosano C., Simonsick E.M., Harris T.B., Kritchevsky S.B., Brach J., Visser M., Yaffe K., Newman A.B. (2005). Association between physical and cognitive function in healthy elderly: the health, aging and body composition study. Neuroepidemiology, 24: 8-14., 10.1159/00008104DOI: 10.1159/00008104
  36. Rovio S., Kåreholt I., Helkala E.L., Viitanen M., Winblad B., Tuomilehto J., Soininen H., Nissinen A., Kivipelto M. (2005). Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease. Lancet Neurol, 4:705-11., 10.1016/S1474-4422(05)70198-DOI: 10.1016/S1474-4422(05)70198-
  37. Rowe J.W., Kahn R.L. (1987). Human aging: usual and successful. Science, 237: 143-49., 10.1126/science.329970DOI: 10.1126/science.329970
  38. Rowe J.W., Kahn R.L. (1997). Successful aging. Gerontologist, 37:433-40., 10.1093/geront/37.4.43DOI: 10.1093/geront/37.4.43
  39. Salthouse T.A. (1996). The processing-speed theory of adult age differences in cognition. Psychol Rev, 103: 403-28
  40. Schneider L.S., Mangialasche F., Andreasen N., Feldman H., Giacobini E., Jones R., Mantua V., Mecocci P., Pani L., Winblad B., Kivipelto M. (2014). Clinical trials and latestage drug development for Alzheimer's disease: an appraisal from 1984 to 2014. J Intern Med, 275: 251-83., 10.1111/joim.1219DOI: 10.1111/joim.1219
  41. Sofi F., Valecchi D., Bacci D., Abbate R., Gensini G.F., Casini A., Macchi C. (2011). Physical activity and risk of cognitive decline: a meta-analysis of prospective studies. J Intern Med, 269: 107-17., 10.1111/j.1365-2796.2010.0228DOI: 10.1111/j.1365-2796.2010.0228
  42. Spada R.S., Stella G., Calabrese S., Bosco P., Anello G., Guéant-Rodriguez R.M., Romano A., Benamghar L., Guéant J.L. (2009). Prevalence of dementia in mountainous village of Sicily. J Neurol Sci, 283: 62-5., 10.1016/j.jns.2009.02.31DOI: 10.1016/j.jns.2009.02.31
  43. Stern Y. (2012) Cognitive reserve in ageing and Alzheimer's disease. Lancet Neurol, 11: 1006–12., 10.1016/S1474-422(12)70191-DOI: 10.1016/S1474-422(12)70191-
  44. Suo C., León I., Brodaty H., Trollor J., Wen W., Sachdev P., Valenzuela M.J. (2012). Supervisory experience at work is linked to low rate of hippocampal atrophy in late life. Neuroimage, 63: 1542-51., 10.1016/j.neuroimage.2012.08.01DOI: 10.1016/j.neuroimage.2012.08.01
  45. Swan G.E., Carmelli D., Reed T., Harshfield G.A., Fabsitz R.R., Eslinger P.J. (1990). Heritability of cognitive performance in aging twins. The National Heart, Lung, and Blood Institute Twin Study. Arch Neurol, 47: 259–62., 10.1001/archneur.1990.0053003002501DOI: 10.1001/archneur.1990.0053003002501
  46. Trittschuh E.H., Crane P.K., Larson E.B., Cholerton B., McCormick W.C., McCurry S.M., Bowen J.D., Baker L.D., Craft S. (2011). Effects of varying diagnostic criteria on prevalence of mild cognitive impairment in a community based sample. J Alzheimers Dis; 25: 163-73., 10.3233/JAD-2011-10182DOI: 10.3233/JAD-2011-10182
  47. Valenzuela M.J., Matthews F.E., Brayne C., Ince P., Halliday G., Kril J.J., Dalton M.A.,Richardson K., Forster G., Sachdev P.S.; Medical Research Council Cognitive Function and Ageing Study. (2012). Multiple biological pathways link cognitive lifestyle to protection from dementia. Biol Psychiatry, 71: 783-91., 10.1016/j.biopsych.2011.07.03DOI: 10.1016/j.biopsych.2011.07.03
  48. Valenzuela M.J., Sachdev P. (2006). Brain reserve and dementia: a systematic review. Psychol Med , 36: 441-54., 10.1017/S003329170500626DOI: 10.1017/S003329170500626
  49. Verghese J., LeValley A., Derby C., Kuslansky G., Katz M., Hall C., Buschke H., Lipton R.B. (2006). Leisure activities and the risk of amnestic mild cognitive impairment in the elderly. Neurology, 66: 821-27., 10.1212/01.wnl.0000202520.68987.4DOI: 10.1212/01.wnl.0000202520.68987.4
  50. Virtanen M., Oksanen T., Batty G.D., Ala-Mursula L., Salo P., Elovainio M., Pentti J., Lybäck K., Vahtera J., Kivimäki M. (2014). Extending employment beyond the pensionable age: a cohort study of the influence of chronic diseases, health risk factors, and
  51. working conditions. PLoS One, 9(2):e88695., 10.1371/journal.pone.008869DOI: 10.1371/journal.pone.008869
  52. Wang H.X., Karp A., Winblad B., Fratiglioni L. (2002). Late-life engagement in social and leisure activities is associated with a decreased risk of dementia: a longitudinal study from the Kungsholmen project. Am J Epidemiol, 155: 1081-87., 10.1093/aje/155.12.108DOI: 10.1093/aje/155.12.108
  53. Weuve J., Kang J.H., Manson J.E., Breteler M.M., Ware J.H., Grodstein F. (2004). Physical
  54. activity, including walking, and cognitive function in older women. JAMA, 292: 1454-61., 10.1001/jama.292.12.145DOI: 10.1001/jama.292.12.145
  55. Whitehouse P.J. (2014). The end of Alzheimer's disease--from biochemical pharmacology to ecopsychosociology: a personal perspective. Biochem Pharmacol.15; 88: 677-81., 10.1016/j.bcp.2013.11.01DOI: 10.1016/j.bcp.2013.11.01
  56. Whitehouse P.J., George D. (2008). The Myth of Alzheimer's: What You Aren't Being Told About Today's Most Dreaded Diagnosis New York: Martin Press (Trd.It: Il mito dell'Alzheimer. Quello che non sai sulla malattia più temuta del nostro tempo. Milano: Cairo Editore, 2011)
  57. Wilson R.S., Mendes de Leon C.F., Barnes L.L., Schneider J.A., Bienias J.L., Evans D.A., Bennett D.A. (2002). Participation in cognitively stimulating activities and risk of incident Alzheimer disease. JAMA, 287: 742-48., 10.1001/jama.287.6.74DOI: 10.1001/jama.287.6.74
  58. Wilson R.S., Scherr P.A., Schneider J.A., Tang Y., Bennett D.A. (2007). Relation of cognitive activity to risk of developing Alzheimer disease. Neurology, 69: 1911-20., 10.1212/01.wnl.0000271087.6778DOI: 10.1212/01.wnl.0000271087.6778
  59. Wimo A., Jönsson L., Bond J., Prince M., Winblad B.; Alzheimer Disease International. (2013). The worldwide economic impact of dementia 2010. Alzheimers Demen, 9(1):1-11.e3., 10.1016/j.jalz.2012.11.00DOI: 10.1016/j.jalz.2012.11.00
  60. World Health Organization (2012). Dementia: a public health priority. Yaffe K., Barnes D., Nevitt M., Lui L.Y., Covinsky K. (2001). A prospective study of physical activity and cognitive decline in elderly women: women who walk. Arch Intern Med, 161: 1703-08., 10.1001/archinte.161.14.170DOI: 10.1001/archinte.161.14.170
  61. Yaffe K., Fiocco A.J., Lindquist K., Vittinghoff E., Simonsick E.M., Newman A.B., Satterfield S., Rosano C., Rubin S.M., Ayonayon H.N., Harris T.B.; Health ABC Study.
  62. (2009). Predictors of maintaining cognitive function in older adults: the Health ABC study. Neurology, 72: 2029-35., 10.1212/WNL.0b013e3181a92c3DOI: 10.1212/WNL.0b013e3181a92c3

Antonio Guaita, in "SALUTE E SOCIETÀ" 1/2016, pp. 55-69, DOI:10.3280/SES2016-001005

   

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