The article presents some reflexions about the use of the Infant Observation Methodology. First the Author outlines briefly the specificity of that method, then she reports some examples crucial as to what can happen into the space-time features of the observation of a mother-child relationship: possible emotional reactions, committments and unconscious identifications; all these becoming then matter of discussion by the study group with a leader. An extension of the Infant Observation about a particularly difficult motherchild relationship is also reported, as well as an application into an Hospital Department, that lets Ostetricians and Nurses work together, focusing on the early post partum mother-child relationship and sharing their own job experiences. The article ends with the report of an Infant Observation of six twins and the subsequent follow-up fifteen years later. It shows some potentially predictive items of psychic development since childhood to adolescence, so stressing the importance of the environment factors on evolutive process.