DiGeorge Syndrome is caused by a deletion of 22 chromosome and in this syndromic framework there is an impairment of dopaminergic network crucial in learning. Reversal learning involves the adaptation of behaviour according to changes in stimulus-reward contingencies; a damage to the orbitofrontal cortex has been linked to impaired renforcement processing. The present study tries to understand if there is a link between DiGeorge Syndrome and the reversal learning ability and so a connection with learning. The study is divided into two parts. In the first part a reversal learning task with probabilistic feedback was administered to 119 children with typical development, split into 3 groups to observe when the reversal learning ability appears. In the second part, a sample of 10 children with DiGeorge Syndrome completed WISC-R in addition to the reversal learning task; they were then compared to 24 children with typical development. Results suggest that the ability of reversal learning appears similarly in children with typical development, and learning seems to be merely slower in DiGeorge Syndrome.
Keywords: Children, DiGeorge Syndrome, reversal, reward, learning.