ADHD and asthma are conditions prevalent in childhood, with a complex pathophysiology involving genetic-environmental interaction. The goal of this article is to explore the factors that can increase the risk of developing asthma in children with ADHD. Babies born prematurely and/or those whose mothers have experienced stress during pregnancy, have a greater risk of developing asthma in conjunction with ADHD, demonstrating how prenatal stress could affect multiple physiopathological circuits. In this process hypothalamic- pituitary-adrenal (HPA) axis activation and inflammatory cytokines mediation are involved, which can determine morphological and functional changes of the brain, and immune alterations that predispose to atopy.
Keywords: Maternal stress, Pregnancy, ADHD, Asthma, Childhood, Inflammatory cytokines.