Epigenetics and cancer

Journal title PNEI REVIEW
Author/s Ketti Mazzocco, Alessandra Milani
Publishing Year 2023 Issue 2023/1
Language Italian Pages 20 P. 68-87 File size 1119 KB
DOI 10.3280/PNEI2023-001005
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In recent years there has been an increase in the incidence and preva- lence of cancer in Italy and worldwide. The post-pandemic mortality rate is also rising compared to previous years. CoViD-19 has, in fact, created a diagnostic delay and a late start of treatment, thus reducing in many cases the probability of healing. Official Italian websites on cancer information (Aimac, Airc), reports from national associations such as the Italian As- sociation of Medical Oncology (Aiom), and the Ministry of Health "can- cer prevention" website describe the main risk factors of cancer disease; no mention was found about the psychological factors despite the growing evidence on their significant contribution. The following narrative review aims to highlight, through complex epigenetic mechanisms, the influence on carcinogenesis of the most well-known and shared risk factors such as lifestyles and environment, but also of less publicized ones such as social environment and self-perception. This complex multifactoriality of cancer disease may represent an opportunity for healthcare professionals to con- sider a patient as a system consistent with the Pnei perspective and to pro- mote an integrated care.

Keywords: Epigenetics, Cancer, Lifestyle, Environment, Psychology, Integrated care

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Ketti Mazzocco, Alessandra Milani, Epigenetica e cancro in "PNEI REVIEW" 1/2023, pp 68-87, DOI: 10.3280/PNEI2023-001005