Promoting resilience in the Italian population against SARS-CoV-2

Journal title PNEI REVIEW
Author/s David Lazzari, Anna Giulia Bottaccioli, Francesco Bottaccioli
Publishing Year 2020 Issue 2020/1
Language Italian Pages 20 P. 6-25 File size 484 KB
DOI 10.3280/PNEI2020-001002
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The Covid-19 pandemic - due to its impact on the wealthiest and most technologically advanced nations, which are experiencing unprecedented experiences of mortality, fear and social isolation, to the difficulties faced by health services and to the uncertainty regarding the evolution of the pandemic and its economic repercussions on a global scale - requires a change in the prevention and treatment of the infection, based on the integration of biomedical and psychological sciences and professions. A survey of the Italian pandemic population shows a widespread state of psychological distress which, based on decades of scientific and clinical evidence on the relationship between mental states and immune system efficiency, plausibly weakens the resistance to SARS-CoV-2 infection. Italy can deploy tens of thousands of psychologists and psychotherapists who, as health workers, could be employed, alongside local and hospital medicine, in primary care and in promoting the resilience of citizens and health workers themselves, who are subject to a work stress that also includes a threat to their lives.

Keywords: Psychoneuroendocrineimmunology, Covid-19, Lockdown distress, Immune equilibrium; Immunity and mental state, Integrated care.

  1. Abd El-Kader S.M. and Al-Shreef F.M. (2018). Inflammatory cytokines and immune system modulation by aerobic versus resisted exercise training for elderly. Afr. Health Sci., 18(1): 120-131.
  2. Ader R. (2007). Psychoneuroimmunology. Fourth ed. San Diego: Academic Press.
  3. Arsenis N.C., You T., Ogawa E.F., Tinsley G.M. and Zuo L. (2017). Physical activity and telomere length: Impact of aging and potential mechanisms of action. Oncotarget, 8(27), 45008-45019.
  4. ARPA (2020). Sito dell’Agenzia Regionale Protezione Ambiente Lombardia. -- Testo disponibile al sito: https://www.arpalombardia.it/, visitato il 24/05/2020.
  5. Beller J. and Wagner A. (2018). Loneliness, social isolation, their synergistic interaction, and mortality. Health Psychol., 37(9): 808-813.
  6. Bottaccioli A.G., Bottaccioli F. and Minelli A. (2019). Stress and the psyche-brain-immune network in psychiatric diseases based on psychoneuroendocrineimmunology: a concise review. Ann. N. Y. Acad. Sci., 1437(1): 31-42.
  7. Bottaccioli F. e Bottaccioli A.G. (2017). Psiconeuroendocrinoimmunologia e scienza della cura integrata. Il Manuale. Milano: Edra.
  8. Bottaccioli F. and Bottaccioli A.G. (2020). Psychoneuroendocrineimmunology and science of integrate care. The Manual. Milano: Edra.
  9. Bower J.E. and Irwin M.R. (2016). Mind-body therapies and control of inflammatory biology: A descriptive review. Brain Behav. Immun., 51: 1-11.
  10. Cao W., Fang Z., Hou G., Han M., Xu X., Dong J. and Zheng J. (2020). The psychological impact of the COVID-19 epidemic on college students in China. Psychiatry Res., 287: 112934
  11. Chen G., Wu D., Guo W., Cao Y., Huang D., Wang H., Wang T., Zhang X., Chen H., Yu H., Zhang X., Zhang M., Wu S., Song J., Chen T., Han M., Li S., Luo X., Zhao J. and Ning Q. (2020). Clinical and immunologic features in severe and moderate Coronavirus Disease 2019. J. Clin. Invest., 130(5): 2620-2629. DOI: 10.1172/JCI13724
  12. Cole S.W., Levine M.E., Arevalo J.M., Ma J., Weir D.R. and Crimmins E.M. (2015). Loneliness, eudaimonia, and the human conserved transcriptional response to adversity. Psychoneuroendocrinology, 62: 11-17.
  13. Coronaviridae Study Group of the International Committee on Taxonomy of Viruses. (2020). The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat. Microbiol., 5(4): 536-544.
  14. CNOP (2020). Linee di indirizzo per l’intervento psicologico a distanza nell’emergenza COVID. -- Testo disponibile al sito: https://d66rp9rxjwtwy.cloudfront.net/wp-content/uploads/2020/04/LINEE-DI-INDIRIZZO-PER-LINTERVENTO-PSICOLOGICO-A-DISTANZA-
  15. A-FAVORE-DELLA-POPOLAZIONE-NELLEMERGENZA-COVID-19-1.pdf, visitato il 24/05/2020.
  16. Deng Y., Liu W., Liu K., Fang Y.Y., Shang J., Zhou L., Wang K., Leng F., Wei S., Chen L. and Liu H.G. (2020). Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study. Chin. Med. J. (Engl). [Epub ahead of print] DOI: 10.1097/CM9.000000000000082
  17. Ding Y., Wang H., Shen H., Li Z., Geng J., Han H., Cai J., Li X., Kang W., Weng D., Lu Y., Wu D., He L. Yao K. (2003). The clinical pathology of severe acute respiratory syndrome (SARS): a report from China. J. Pathol., 200(3): 282-289.
  18. Dossett M.L., Fricchione G.L. and Benson H. (2020). A New Era for Mind-Body Medicine. N. Engl. J. Med., 382(15): 1390-1391.
  19. EEA. (2019). Air quality in Europe – 2019 Report. Luxembourg: Publications Office of the European Union.
  20. Fracastoro G. (1546). De contagionibus et contagiosis morbis et eorum curatione. Testo italiano disponibile al sito: http://biochimica.bio.uniroma1.it/bfracastoro1.pdf, visitato il 24/05/2020.
  21. Franceschi C., Garagnani P., Parini P., Giuliani C. and Santoro A. (2018). Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nat. Rev. Endocrinol., 14(10): 576-590.
  22. Gialluisi A., Bonaccio M., Di Castelnuovo A., Costanzo S., De Curtis A., Sarchiapone M., Cerletti C., Donati M.B., de Gaetano G., Iacoviello L. and Moli-Sani Study Investigators. (2020). Lifestyle and biological factors influence the relationship between mental health and low-grade inflammation. Brain Behav. Immun., 85: 4-13.
  23. Grégoire M., Uhel F., Lesouhaitier M., Gacouin A., Guirriec M., Mourcin F., Dumontet E., Chalin A., Samson M., Berthelot L.L., Tissot A., Kerjouan M., Jouneau S., Le Tulzo Y., Tarte K., Zmijewski J.W. and Tadié J.M. (2018). Impaired efferocytosis and neutrophil extracellular trap clearance by macrophages in ARDS. Eur. Respir. J., 52: 1702590. DOI: 10.1183/13993003.02590-201
  24. Holmes E.A., O’Connor R.C., Perry V.H., Tracey I., Wessely S., Arseneault L., Ballard C., Christensen H., Cohen Silver R., Everall I., Ford T., John A., Kabir T., King K., Madan I., Michie S., Przybylski A.K., Shafran R., Sweeney A., Worthman, C. M., Yardley L., Cowan K., Clope C., Hotopf M. and Bullmore E. (2020). Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science. Lancet Psychiatry, 7(6): 547-560.
  25. IASC Reference Group on Mental Health and Psychosocial Support in Emergency Settings (2020). Gestire la salute mentale e gli aspetti psicosociali dell’epidemia di COVID-19. -- Testo disponibile al sito: https://interagencystandingcommittee.org/system/files/2020-03/IASC%20Interim%20Briefing%20Note%20on%20COVID-19%20Outbreak%20Readiness%20and%20Response%20Operations%20-%20MHPSS.%20%28Italian%29.pdf, visitato il 24/05/2020.
  26. INAIL e CNOP (2020). Gestione dello stress e prevenzione del burnout negli operatori sanitari nell’emergenza Covid-19. Testo disponibile al sito: https://www.inail.it/cs/internet/attivita/ricerca-e-tecnologia/area-salute-sul-lavoro/rischi-psicosociali-e-tutela-dei-lavoratori-vulnerabili/Covid-19-gestione-stress-e-prevenzione-burnout.html, visitato il 24/05/2020.
  27. INPS (2020). Analisi della mortalità nel periodo di epidemia da Covid-19. -- Testo disponibile al sito: https://www.inps.it/docallegatiNP/Mig/Dati_analisi_bilanci/Nota_CGSA_mortal_Covid19_def.pdf, visitato il 24/05/2020.
  28. ISS (2020a). Indicazioni ad interim per servizi assistenziali di telemedicina durante l’emergenza sanitaria COVID-19. -- Testo disponibile al sito: https://www.iss.it/documents/20126/0/Rapporto+ISS+COVID-19+n.+12+telemedicina.pdf/37b4b856-603a-76c1-1b85-5ff9c662bbbb? t=1586860608120, visitato il 24/05/2020.
  29. ISS (2020b). Caratteristiche dei pazienti deceduti positivi all’infezione da SARS-CoV-2 in Italia. Dati al 21 maggio 2020. -- Testo disponibile al sito: https://www.epicentro.iss.it/coronavirus/bollettino/Report-COVID-2019_21_maggio.pdf, visitato il 24/05/2020.
  30. ISTAT (2013). Indagine multiscopo sulle famiglie, “Condizioni di salute e ricorso ai servizi sanitari”. Roma: ISTAT.
  31. JHU CSSE (2020). COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU). -- Testo disponibile al sito: https://coronavirus.jhu.edu/map.html, visitato il 24/05/2020.
  32. Jiménez-Pavón D., Carbonell-Baeza A. and Lavie C.J. (2020). Physical exercise as therapy to fight against the mental and physical consequences of COVID-19 quarantine: Special focus in older people. Prog. Cardiovasc. Dis. [Epub ahead of print]
  33. Kim S.W. and Su K.P. (2020). Using psychoneuroimmunity against COVID-19. Brain Behav Immun. [Epub ahead of print]
  34. Lai J., Ma S., Wang Y., Cai Z., Hu J., Wei N., Wu J., Du H., Chen T., Li R., Tan H., Kang L., Yao L., Huang M., Wang H., Wang G., Liu Z. and Hu S. (2020). Factors Associated With Mental Health Outcomes Among Health Care Workers Exposed to Coronavirus Disease 2019. JAMA Netw. Open, 3(3): e203976.
  35. Lazzari D. (2019). La Psiche tra Salute e Malattia. Evidenze ed epidemiologia. Milano: Edra.
  36. Lazzari D., Bottaccioli A.G. and Bottaccioli F. (2020). Letter to the Editor: Kim, S.-W., Su, K.-P. (2020) Using psychoneuroimmunity against COVID-19, Brain, Behavior, and Immunity (2020),
  37. Leday G.G.R., Vértes P.E., Richardson S., Greene J.R., Regan T., Khan S., Henderson R., Freeman T. C., Pariante C.M., Harrison N.A., MRC Immunopsychiatry Consortium, Perry V.H., Drevets W.C., Wittenberg G.M. and Bullmore E.T. (2018). Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive Disorder. Biol. Psychiatry. 83(1), 70-80.
  38. Li L.Y., Wu W., Chen S., Gu J.W., Li X.L., Song H.J., Du F., Wang G., Zhong C.Q., Wang X.Y., Chen Y., Shah R., Yang H.M. and Cai Q. (2020). Digestive system involvement of novel coronavirus infection: prevention and control infection from a gastroenterology perspective. J. Dig. Dis., 21(4): 199-204. DOI: 10.1111/1751-2980.1286
  39. Liang T., ed. (2020). Manuale di Prevenzione e Trattamento COVID-19. Compilato secondo l’esperienza clinica. -- Testo disponibile al sito: https://gmcc.alibabadoctor.com/prevention-manual/reader?pdf=Handbook%20of%20COVID-19%20Prevention%20and%20Treatment%20(Standard)-Italian.pdf&opt=read&version=standard&language=it&content_id=, visitato il 24/05/2020.
  40. Maggini S., Pierre A. and Calder P.C. (2018). Immune Function and Micronutrient Requirements Change over the Life Course. Nutrients, 10(10): 1531.
  41. McEwen C.A. and McEwen B.S. (2017). Social Structure, Adversity, Toxic Stress, and Intergenerational Poverty: An Early Childhood Model. Annu. Rev. Sociol. 43, 445-472.
  42. Nguyen H.C., Nguyen M.H., Do B.N., Tran C.Q., Nguyen T., Pham K.M., Pham L.V., Tran K.V., Duong T.T., Tran T.V., Duong T.H., Nguyen T.T., Nguyen Q.H., Hoang T.M., Nguyen K.T., Pham T., Yang S.H., Chao J.C. and Duong T.V. (2020). People with Suspected COVID-19 Symptoms Were More Likely Depressed and Had Lower Health-Related Quality of Life: The Potential Benefit of Health Literacy. J. Clin. Med., 9(4): 965.
  43. Open Evidence (2020). How are organisations adapting to the #Covid19 #pandemic in Italy, Spain and UK?. -- Testo disponibile al sito: https://www.linkedin.com/company/open-evidence/?originalSubdomain=it, visitato il 24/05/2020.
  44. Pariante C.M. (2017). Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation. Eur. Neuropsychopharmacol., 27(6): 554-559.
  45. Papayannopoulos V. (2018). Neutrophil extracellular traps in immunity and disease. Nat. Rev. Immunol., 18(2): 134-147.
  46. Pfefferbaum B. and North S.C. (2020). Mental Health and the Covid-19 Pandemic. N. Engl. J. Med. [Epub ahead of print]
  47. Qin C., Zhou L., Hu Z., Zhang S., Yang S., Tao Y., Xie C., Ma K., Shang K., Wang W. and Tian D.S. (2020). Dysregulation of immune response in patients with COVID-19 in Wuhan, China. Clin. Infect. Dis. [Epub ahead of print]
  48. Ritchie H. and Roser M. (2018). Mental health. -- Testo disponibile al sito: https://ourworldindata.org/mental-health, visitato il 24/05/2020.
  49. Salazar N., Valdés-Varela L., González S., Gueimonde M. and de Los Reyes-Gavilán CG. (2017). Nutrition and the gut microbiome in the elderly. Gut Microbes. 8(2): 82-97. DOI: 10.1080/19490976.2016.125652
  50. Schmidt T., van Mackelenbergh M., Wesch D. and Mundhenke C. (2017). Physical activity influences the immune system of breast cancer patients. J. Cancer Res. Ther. 13(3): 392-398. DOI: 10.4103/0973-1482.15035
  51. SINUC e SIAARTI (2020). Raccomandazioni per il trattamento nutrizionale di pazienti affetti da Covid-19 e ricoverati nei reparti di Terapia Intensiva e Sub-Intensiva (Level III-II Care) - versione 01. Pubblicato il 04.04.2020. -- Testo disponibile al sito: http://www.sinuc.it/public/files/SINuC-SIAARTI%20-%20RACCOMANDAZIONI%20PER%20IL%20TRATTAMENTO%20NUTRIZIONALE%20DI%20PAZIENTI%20AFFETTI%20DA%20COVID-19.pdf, visitato il 24/05/2020
  52. Steel Z., Marnane C., Iranpour C., Chey T., Jackson J.W., Patel V. and Silove D. (2014). The global prevalence of common mental disorders: a systematic review and meta-analysis 1980-2013. Int. J. Epidemiol., 43(2), 476-493.
  53. Terpos E., Ntanasis-Stathopoulos I., Elalamy I., Kastritis E., Sergentanis T.N., Politou M., Psaltopoulou T., Gerotziafas G. and Dimopoulos M.A. (2020). Hematological findings and complications of COVID-19. Am. J. Hematol. [Epub ahead of print]
  54. Udell J.A., Steg P.G., Scirica B.M., Smith S.C. Jr, Ohman E.M., Eagle K.A., Goto S., Cho J.I., Bhatt D.L. and REduction of Atherothrombosis for Continued Health (REACH) Registry Investigators (2012). Living alone and cardiovascular risk in outpatients at risk of or with atherothrombosis. Arch. Intern. Med., 14: 1086-1095.
  55. Van Avondt K. and Hartl D. (2018). Mechanisms and disease relevance of neutrophil extracellular trap formation. Eur. J. Clin. Invest., 48 Suppl 2: e12919.
  56. van Doremalen N., Bushmaker T., Morris D.H., Holbrook M.G., Gamble A., Williamson B.N., Tamin A., Harcourt J.L., Thornburg N.J., Gerber S.I., Lloyd-Smith J.O., de Wit E. and Munster V.J. (2020). Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. N. Engl. J. Med., 382(16): 1564-1567.
  57. Villalba D.K., Lindsay E.K., Marsland A.L., Greco C.M., Young S., Brown K.W., Smyth, J. M., Walsh C.P., Gray K., Chin B. and Creswell J.D. (2019). Mindfulness training and systemic low-grade inflammation in stressed community adults: Evidence from two randomized controlled trials. PLoS One, 14(7): e0219120.
  58. Wan Y., Shang J., Graham R., Baric R.S. and Li F. (2020). Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus. 2020. J. Virol., 94(7): e00127-e00120. DOI: 10.1128/JVI.00127-2
  59. Wang C., Pan R., Wan X., Tan Y., Xu L., Ho C.S. and Ho R.C. (2020). Immediate Psychological Responses and Associated Factors during the Initial Stage of the 2019 Coronavirus Disease (COVID-19) Epidemic among the General Population in China. Int. J. Environ. Res. Public Health, 17(5): 1729.
  60. Wang D., Hu B., Hu C., Zhu F., Liu X., Zhang J., Wang B., Xiang H., Cheng Z., Xiong Y., Zhao Y., Li Y., Wang X. and Peng Z. (2020). Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA, 323(11): 1061-1069. [Epub ahead of print]
  61. Wu X., Nethery R.C., Sabath M.B., Braun D. and Dominici F. (2020). Exposure to air pollution and COVID-19 mortality in the United States. medRxiv, 2020.04.05.20054502. DOI: 10.1101/2020.04.05.2005450
  62. Xu Y.H., Dong J.H., An W.M., Lv X.Y., Yin X.P., Zhang J.Z., Dong L., Ma X., Zhang H.J. and Gao B.L. (2020). Clinical and computed tomographic imaging features of novel coronavirus pneumonia caused by SARS-CoV-2. J. Infect., 80(4): 394-400.
  63. Yang L., Li C. and Tang X. (2020). The Impact of PM2.5 on the Host Defense of Respiratory System. Front. Cell. Dev. Biol., 8: 91.
  64. Zhang X., Lei B., Yuan Y., Zhang L., Hu L., Jin S., Kang B., Liao X., Sun W., Xu F., Zhong Y., Hu J. and Qi H. (2020). Brain control of humoral immune responses amenable to behavioural modulation. Nature, 581(7807): 204-208.

David Lazzari, Anna Giulia Bottaccioli, Francesco Bottaccioli, Promuovere la resilienza della popolazione italiana contro SARS-CoV-2 in "PNEI REVIEW" 1/2020, pp 6-25, DOI: 10.3280/PNEI2020-001002