Alzheimer’s disease: A modern view of an ancient story

Journal title PNEI REVIEW
Author/s Paola Colagrande, Annalisa Ghiglia, Pierluigia Verga
Publishing Year 2020 Issue 2020/1
Language Italian Pages 9 P. 61-69 File size 543 KB
DOI 10.3280/PNEI2020-001008
DOI is like a bar code for intellectual property: to have more infomation click here

Below, you can see the article first page

If you want to buy this article in PDF format, you can do it, following the instructions to buy download credits

Article preview

FrancoAngeli is member of Publishers International Linking Association, Inc (PILA), a not-for-profit association which run the CrossRef service enabling links to and from online scholarly content.

Alzheimer’s disease (AD) involves impairment of the cognitive sphere, motor skills and higher functions, progressive deconstruction of the mind-body system and loss of autonomy. The brain with AD shows extracellular amyloid-β plaques, intraneuronal tangles of hyperphosphorylated tau, and inflammation. The article presents the pathogenesis, the possible prevention and treatment of AD according to the Pnei paradigm: modifiable and unchangeable risk factors are known. Among the formers, a preventive role is assigned to certain behaviors: a correct diet, regular physical activity, the maintenance of significant interpersonal bonds, the control of cardiovascular risk, protection from psychoemotional stress, early treatment of depression and abstention from alcohol and tobacco. The Pnei approach guarantees a systemic look at the clinical-metabolic manifestations of AD (disease), the patient’s experience of illness (illness) and the possibility of residual autonomy (sickness). At present, the study courses on AD created by multidisciplinary teams of professionals, integrated with each other, are increasingly valid.

Keywords: Alzheimer’s disease, Stress, Risk factors, Prevention, Early diagnosis, Multidisciplinary treatment.

  1. Armstrong A.R. (2019). Risk factors for Alzheimer’s disease. Folia Neuropathol., 57(2): 87-105.
  2. Bisht K., Sharma K. and Tremlay ME. (2018). Chronic stress as a risk factor for Alzheimer’s disease: roles of microglia-mediated synaptic remodeling, inflammation, and oxidative stress. Neurobiol. Stress, 9: 9-21.
  3. Bottaccioli F. e Bottaccioli A.G. (2017). Psiconeuroendocrinoimmunologia e scienza della cura integrata. Il Manuale. Milano: Edra.
  4. Bottaccioli F. e Carosella A. (2011). Menta inquieta. Milano: Tecniche nuove.
  5. D’Amelio M., Nobili A., Latagliata E.C., Viscomi M.T., Cavallucci V., Cutuli D., Giacovazzo G., Kraashia P., Rizzo F.R., Marino R., Federici M., Aversa D., Dell’Acqua M.C., Cordella A., Sancandi M., Keller F., Puglisi-Allegra S., Mercuri N.B., Coccurello A. and Beretta N. (2017). Dopamine neuronal loss contributes to memory and renard dysfunction in a model of Alzheimer’s disease. Nat. Commun., 8: 14727.
  6. Prince M., Ali G.C., Guerchet M., Prina A.M., Albanese E. and Wu Y.T. (2016). Recent global trends in the prevalence and incidence of dementia, and survival with dementia. Alzheimers Res. Ther., 8(1): 23.
  7. Schelke M.W., Attia P., Palenchar D.J., Kaplan B., Mureb M., Ganzer C.A., Scheyer O., Rahman A., Kachko R., Krikorian R., Mosconi L. and Isaacson R.S. (2018). Mechanisms of risk reduction in the clinical practice of Alzheimer’s disease prevention. Front. in Aging Neurosci., 10: 96.
  8. Vlachos G.S. and Scarmeas N. (2019). Dietary interventions in mild cognitive impairment and dementia. Dialogues Clin. Neurosci., 21(1): 69-82.
  9. Wang J., Cu B.J., Masters C.L. and Wang Y.J. (2017). A systemic view of Alzheimer disease-insights from amyloid – β metabolism beyond the brain. Nat. Rev. Neurol., 13: 612-623.

Paola Colagrande, Annalisa Ghiglia, Pierluigia Verga, Malattia di Alzheimer: una storia antica in ottica moderna in "PNEI REVIEW" 1/2020, pp 61-69, DOI: 10.3280/PNEI2020-001008