Peripheral blood infl ammatory markers as signals of mental disorders in a sample of elderly people

Titolo Rivista PNEI REVIEW
Autori/Curatori Ciro D’Auria
Anno di pubblicazione 2023 Fascicolo 2023/1
Lingua Inglese Numero pagine 17 P. 106-122 Dimensione file 1122 KB
DOI 10.3280/PNEI2023-001007
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The physiological epiphenomena and the concurrent and altered emotional and cognitive states exhibit themselves in the brain and peripherally as well. Depres- sion also carries allostatic changes related to inflammation and hormonal imba- lances, the same applies to anxiety and cognitive impairments. After examining alterations in scientific literature, we proceed with a cross-sectional study consi- dering a sample made of a group of elderly people from Northern Italy, in order to highlight potentially altered hematic levels of inflammatory markers in the serum in combination with depression, anxiety, and cognitive impairment me- asurements. As far as we know, inflammatory markers such as PLR and MLR have never been studied for this purpose in the elderly. Results exhibit differen- ces in the PLR between people with and without depression, differences in the NLR, PLR, and MLR between people with anxiety, and a predictive value in the WBC parameter, PLR, and TSH related to the cognitive state. The data suggest that, in given circumstances, inflammatory markers taken from plasma could help diagnose mental disorders and develop targeted treatments.

Gli epifenomeni fisiologici concomitanti gli stati emotivi o cognitivi alterati sono conclamati non solo nel cervello, ma anche perifericamente. La depressione por- ta con sé modificazioni allostatiche relative a stati infiammatori e valori ormona- li alterati, e lo stesso è stato indagato per l’ansia e i deficit cognitivi. Esaminate certe modificazioni nella letteratura scientifica, si avanza uno studio trasversale che prevede il campionamento di un gruppo di anziani del nord Italia, col fine di evidenziare valori ematici alterati e marker infiammatori nel siero in concomitanza con misurazioni relative alla depressione, all’ansia e allo stato cognitivo. Marker infiammatori come il PLR e l’MLR, per quanto ne sappiamo, non sono mai stati studiati con lo stesso fine in una popolazione di anziani. I risultati hanno eviden- ziato una differenza fra le persone depresse e non depresse nel PLR, differenze fra le persone ansiose nell’NLR, nel PLR e nell’MLR, mentre per lo stato cognitivo abbiamo notato un valore predittivo nel parametro WBC, nel PLR e nel TSH. I dati ci indicano che, a determinate condizioni, i marker infiammatori presenti ed evidenziati nel plasma potrebbero contribuire alla diagnosi e all’elaborazione di trattamenti più mirati per i disturbi mentali.

Keywords:Pnei, Depressione, Ansia, Compromissione cognitiva, Marker infiam- matori, Anziani.

  1. Abou-Saleh M.T., & Coppen A. (1989). The efficacy of low-dose lithium: clinical, psycho- logical and biological correlates. Journal of psychiatric research, 23(2), 157–162. DOI: 10.1016/0022-3956(89)90006-
  2. Alexopoulos G.S., & Kelly R.E., Jr (2009). Research advances in geriatric depression. Wor- ld psychiatry: official journal of the World Psychiatric Association (WPA), 8(3), 140–149.
  3. Alexopoulos G.S., & Morimoto S.S. (2011). The inflammation hypothesis in geriatric depression. International journal of geriatric psychiatry, 26(11), 1109–1118.
  4. Alexopoulos G.S., Meyers B.S., Young R.C., Campbell S., Silbersweig D., & Charlson M. (1997). 'Vascular depression' hypothesis. Archives of general psychiatry, 54(10), 915–922.
  5. An P., Zhou X., Du Y., Zhao J., Song A., Liu H., Ma F., & Huang G. (2019). Asso- ciation of Neutrophil-Lymphocyte Ratio with Mild Cognitive Impairment in Elderly Chinese Adults: A Case-control Study. Current Alzheimer research, 16(14), 1309– 1315. DOI: 10.2174/156720501766620010311052
  6. Andrade L., Caraveo-Anduaga J.J., Berglund P., Bijl R.V., De Graaf R., Volleber- gh W., Dragomirecka E., Kohn R., Keller M., Kessler R.C., Kawakami N., Kiliç C., Offord D., Ustun T.B., & Wittchen H.U. (2003). The epidemiology of major depressive episodes: results from the International Consortium of Psychiatric Epide- miology (ICPE) Surveys. International Journal of Methods in Psychiatric Research, 12(1), 13–21.
  7. Arabska J., Łucka A., Magierski R., Sobów T., & Wysokiński A. (2018). Neu- trophil-lymphocyte ratio is increased in elderly patients with first episode depres- sion, but not in recurrent depression. Psychiatry research, 263, 35–40.
  8. Asik Z., & Özen M. (2022). Evaluation of frailty and neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios relationship in elderly people. Nagoya journal of medi- cal science, 84(1), 101–110.
  9. Baykan H., Baykan O., Esen E.C. Tirak A., Gorgulu S.A., & Karlidere T. (2018). Neutrophil-to-Lymphocyte Ratio as a Potential Differential Diagnostic Marker for Alzheimer’s Disease, Major Depressive Disorder, and Parkinson’s Disease. Dusunen Adam The Journal of Psychiatry and Neurological Sciences, 4(31), 389–395. DOI: 10.5350/DAJPN201831040
  10. Mohn C., & Rund B.R. (2016). Neurocognitive profile in major depressive disorders: relationship to symptom level and subjective memory complaints. BMC psychiatry, 16, 108.
  11. Bulut N.S., Yorguner N., & Çarkaxhiu Bulut G. (2021). The severity of inflam- mation in major neuropsychiatric disorders: comparison of neutrophil-lymphocyte and platelet-lymphocyte ratios between schizophrenia, bipolar mania, bipolar depres- sion, major depressive disorder, and obsessive compulsive disorder. Nordic journal of psychiatry, 75(8), 624–632. DOI: 10.1080/08039488.2021.191920
  12. Byrne G.J., & Pachana N.A. (2010). Anxiety and depression in the elderly: do we know any more? Current opinion in psychiatry, 23(6), 504–509.
  13. Carpentier P.A., & Palmer T.D. (2009). Immune influence on adult neural stem cell regulation and function. Neuron, 64(1), 79–92.
  14. Chachamovitz D.S., Vigário P.dosS., Silva S.O., Teixeira L.B., Fagundes M.L., Vaisman M., & Teixeira P.deF. (2016). Does low-normal serum TSH level adversely impact cognition in elderly adults and might methimazole therapy improve outcomes? Endocrine journal, 63(5), 495–505.
  15. Demir S., Atli A., Bulut M., İbiloğlu A. O., Güneş M., Kaya M.C., Demirpençe Ö., & Sır A. (2015). Neutrophil-lymphocyte ratio in patients with major depressive disor- der undergoing no pharmacological therapy. Neuropsychiatric disease and treatment, 11, 2253–2258. DOI: 10.2147/NDT.S8947
  16. Demircan F., Gözel N., Kılınç F., Ulu R., & Atmaca M. (2016). The Impact of Red Blo- od Cell Distribution Width and Neutrophil/Lymphocyte Ratio on the Diagnosis of Major Depressive Disorder. Neurology and therapy, 5(1), 27–33.
  17. Depp C.A., & Jeste D.V. (2006). Definitions and predictors of successful aging: a comprehensive review of larger quantitative studies. The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry, 14(1), 6–20.
  18. Dhabhar F.S. (2014). Effects of stress on immune function: the good, the bad, and the beautiful. Immunologic research, 58(2-3), 193–210.
  19. Ershler W.B., Sun W.H., Binkley N., Gravenstein S., Volk M. J., Kamoske G., Klopp R.G., Roecker E.B., Daynes R.A., & Weindruch R. (1993). Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction. Lymphokine and cytokine research, 12(4), 225–230.
  20. Fillit H., Nash D.T., Rundek T., & Zuckerman A. (2008). Cardiovascular risk factors and dementia. The American journal of geriatric pharmacotherapy, 6(2), 100–118.
  21. Folstein M.F., Folstein S.E., & McHugh P.R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of psychiatric research, 12(3), 189–198. DOI: 10.1016/0022-3956(75)90026-
  22. Frasure-Smith N., & Lespérance F. (2005). Reflections on depression as a cardiac risk factor. Psychosomatic medicine, 67 Suppl 1, S19–S25.
  23. Fu C., Jin X., Chen B., Xue F., Niu H., Guo R., Chen Z., Zheng H., Wang L., & Zhang
  24. Y. (2017). Comparison of the Mini-Mental State Examination and Montreal Cognitive Assessment executive subtests in detecting post-stroke cognitive impairment. Geriatrics & gerontology international, 17(12), 2329–2335.
  25. Gibson P.H., Cuthbertson B.H., Croal B.L., Rae D., El-Shafei H., Gibson G., Jeffrey R.R., Buchan K.G., & Hillis G.S. (2010). Usefulness of neutrophil/lymphocyte ratio as predictor of new-onset atrial fibrillation after coronary artery bypass grafting. The Ameri- can journal of cardiology, 105(2), 186–191.
  26. Godbout J.P., & Johnson R.W. (2006). Age and neuroinflammation: a lifetime of psycho- neuroimmune consequences. Neurologic clinics, 24(3), 521–538.
  27. Hager K., Machein U., Krieger S., Platt D., Seefried G., & Bauer J. (1994). Interleu- kin-6 and selected plasma proteins in healthy persons of different ages. Neurobiology of aging, 15(6), 771–772. DOI: 10.1016/0197-4580(94)90066-
  28. IBM Corp. (2013). IBM SPSS Statistics for Windows (Version 27.0) [Computer software]. IBM Corp.
  29. Imtiaz F., Shafique K., Mirza S.S., Ayoob Z., Vart P., & Rao S. (2012). Neutrophil lym- phocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. International archives of medicine, 5(1), 2. DOI: 10.1186/1755-7682-5-
  30. Ishii T., & Haga S. (1975). Identification of components of immunoglobulins in senile plaques by means of fluorescent antibody technique. Acta neuropathologica, 32(2), 157–162. DOI: 10.1007/BF0068956
  31. Kalelioglu T., Yuruyen M., Gultekin G., Yavuzer H., Özturk Y., Kurt M., Topcu Y., Doventas A., & Emul M. (2017). Neutrophil and platelet to lymphocyte ratios in peo- ple with subjective, mild cognitive impairment and early Alzheimer's disease. Psycho- geriatrics: the official journal of the Japanese Psychogeriatric Society, 17(6), 506–508.
  32. Kao T.W., Chang Y.W., Chou C.C., Hu J., Yu Y.H., & Kuo H.K. (2011). White blood cell count and psychomotor cognitive performance in the elderly. European journal of clinical investigation, 41(5), 513–520.
  33. Kayhan F., Gündüz Ş., Ersoy S.A., Kandeğer A., & Annagür B.B. (2017). Rela- tionships of neutrophil-lymphocyte and platelet-lymphocyte ratios with the severi- ty of major depression. Psychiatry research, 247, 332–335.
  34. Krogh J., Benros M.E., Jørgensen M.B., Vesterager L., Elfving B., & Nordentoft
  35. M. (2014). The association between depressive symptoms, cognitive function, and in- flammation in major depression. Brain, behavior, and immunity, 35, 70–76.
  36. Lasselin J., Kemani M.K., Kanstrup M., Olsson G.L., Axelsson J., Andreasson A., Lekander M., & Wicksell R.K. (2016). Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults. Journal of behavioral medicine, 39(5), 916–924.
  37. Liang M., Du B., Zhang H., Lu X., Chen C., Fan C., & Bi X. (2020). NLR Is Associated With Geriatric Depression in Chinese Women: A Community-Based Cross-Sectional Study in Eastern China. Frontiers in psychology, 10, 2941.
  38. Lucin K.M., & Wyss-Coray T. (2009). Immune activation in brain aging and neuro- degeneration: too much or too little? Neuron, 64(1), 110–122.
  39. Maggio M., Basaria S., Ble A., Lauretani F., Bandinelli S., Ceda G.P., Valenti G., Ling S.M., & Ferrucci L. (2006). Correlation between testosterone and the inflamma- tory marker soluble interleukin-6 receptor in older men. The Journal of clinical endocri- nology and metabolism, 91(1), 345–347.
  40. Marazziti D., Torrigiani S., Carbone M.G., Mucci F., Flamini W., Ivaldi T., & Dell'Osso L. (2022). Neutrophil/Lymphocyte, Platelet/Lymphocyte, and Monocyte/ Lymphocyte Ratios in Mood Disorders. Current medicinal chemistry, 29(36), 5758–5781. DOI: 10.2174/092986732866621092216011
  41. Mazza M.G., Lucchi S., Tringali A.G. M., Rossetti A., Botti E.R., & Clerici M. (2018). Neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in mood disorders: A meta-analysis. Progress in neuro-psychopharmacology & biological psychiatry, 84(Pt A), 229–236.
  42. Meng F., Yan X., Qi J., & He F. (2022). Association of neutrophil to lymphocyte ra- tio, platelet to lymphocyte ratio, and monocyte to lymphocyte ratio with depression: A cross-sectional analysis of the NHANES data. Journal of affective disorders, 315, 168–173.
  43. Moore K., Hughes C.F., Hoey L., Ward M., Cunningham C., Molloy A.M., Strain J.J., McCarroll K., Casey M.C., Tracey F., Laird E., O'Kane M., & McNulty H. (2019). B-vitamins in Relation to Depression in Older Adults Over 60 Years of Age: The Trinity Ulster Department of Agriculture (TUDA) Cohort Study. Journal of the Ame- rican Medical Directors Association, 20(5), 551–557.e1.
  44. Morris M.S., Fava M., Jacques P.F., Selhub J., & Rosenberg I.H. (2003). Depression and folate status in the US Population. Psychotherapy and psychosomatics, 72(2), 80–87. DOI: 10.1159/00006869
  45. Nishijima T.F., Deal A.M., Williams G.R., Guerard E.J., Nyrop K.A., & Muss H.B. (2017). Frailty and inflammatory markers in older adults with cancer. Aging, 9(3), 650– 664.
  46. Olafiranye O., Jean-Louis G., Zizi F., Nunes J., & Vincent M. (2011). Anxiety and cardiovascular risk: Review of Epidemiological and Clinical Evidence. Mind & brain: the journal of psychiatry, 2(1), 32–37.
  47. Öztürk Z.A., Türkbeyler İ.H., Abiyev A., Kul S., Edizer B., Yakaryılmaz F.D., & Soylu G. (2018). Health-related quality of life and fall risk associated with age-related body composition changes; sarcopenia, obesity and sarcopenic obesity. Internal medicine journal, 48(8), 973–981.
  48. Pachana N.A., Byrne G.J., Siddle H., Koloski N., Harley E., & Arnold E. (2007). Development and validation of the Geriatric Anxiety Inventory. International psychoge- riatrics, 19(1), 103–114. DOI: 10.1017/S104161020600350
  49. Raison C.L., Capuron L., & Miller A.H. (2006). Cytokines sing the blues: inflamma- tion and the pathogenesis of depression. Trends in Immunology, 27(1), 24–31.
  50. Rogers J., Luber-Narod J., Styren S.D., & Civin W.H. (1988). Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer's disease. Neurobiology of aging, 9(4), 339–349.
  51. Russo I., Berti G., Plotegher N., Bernardo G., Filograna R., Bubacco L., & Greggio
  52. E. (2016). Erratum to: Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells. Journal of neuroin- flammation, 13(1), 70.
  53. Segerstrom S.C., & Miller G.E. (2004). Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychological bulletin, 130(4), 601–630. DOI: 10.1037/0033-2909.130.4.60
  54. Sheikh J.I., & Yesavage J.A. (1986). Geriatric Depression Scale (GDS): Recent Eviden- ce and Development of a Shorter Version. Clinical Gerontologist: The Journal of Aging and Mental Health, 5, 165–173.
  55. Shui L., Da J.J., He P.H., Li Q., Ou Q.Q., & Zha Y. (2021). [Relationship between pla- telet/lymphocyte ratio and cognitive impairment in diabetic patients treated with mainte- nance hemodialysis]. Zhonghua yi xue za zhi, 101(10), 722–726.
  56. Su M., Ouyang X., & Song Y. (2022). Neutrophil to lymphocyte ratio, platelet to lym- phocyte ratio, and monocyte to lymphocyte ratio in depression: A meta-analysis. Journal of affective disorders, 308, 375–383.
  57. Swardfager W., Rosenblat J.D., Benlamri M., & McIntyre R.S. (2016). Mapping in- flammation onto mood: Inflammatory mediators of anhedonia. Neuroscience and bio- behavioral reviews, 64, 148–166.
  58. Tayde P.S., Bhagwat N.M., Sharma P., Sharma B., Dalwadi P.P., Sonawane A., Subramanyam A., Chadha M., & Varthakavi P.K. (2017). Hypothyroidism and Depres
  59. sion: Are Cytokines the Link? Indian journal of endocrinology and metabolism, 21(6), 886–892.
  60. Turkmen K., Erdur F.M., Ozcicek F., Ozcicek A., Akbas E.M., Ozbicer A., Demir- tas L., Turk S., & Tonbul H.Z. (2013). Platelet-to-lymphocyte ratio better predicts inflammation than neutrophil-to-lymphocyte ratio in end-stage renal disease patients. Hemodialysis international. International Symposium on Home Hemodialysis, 17(3), 391–396.
  61. Uzun N., & Akıncı M.A. (2021). Hemogram parameters in childhood anxiety disor- ders: Could anxiety disorders be related with inflammation? Medical hypotheses, 146, 110440.
  62. Van der Willik K.D., Koppelmans V., Hauptmann M., Compter A., Ikram M.A., & Schagen S.B. (2018). Inflammation markers and cognitive performance in breast cancer survivors 20 years after completion of chemotherapy: a cohort study. Breast cancer research: BCR, 20(1), 135.
  63. Wei J., Xu H., Davies J.L., & Hemmings G.P. (1992). Increase of plasma IL-6 con- centration with age in healthy subjects. Life sciences, 51(25), 1953–1956. DOI: 10.1016/0024-3205(92)90112-
  64. Winchester L.M., Powell J., Lovestone S., & Nevado-Holgado A.J. (2018). Red blood cell indices and anaemia as causative factors for cognitive function deficits and for Alzheimer's disease. Genome medicine, 10(1), 51.
  65. Yaprak M., Turan M.N., Dayanan R., Akın S., Değirmen E., Yıldırım M., & Turgut F. (2016). Platelet-to-lymphocyte ratio predicts mortality better than neu- trophil-to-lymphocyte ratio in hemodialysis patients. International urology and ne- phrology, 48(8), 1343–1348.
  66. Yesavage J.A., Brink T.L., Rose T.L., Lum O., Huang V., Adey M., & Leirer
  67. V.O. (1982). Development and validation of a geriatric depression screening sca- le: a preliminary report. Journal of psychiatric research, 17(1), 37–49. DOI: 10.1016/0022-3956(82)90033-

Ciro D’Auria, Peripheral blood infl ammatory markers as signals of mental disorders in a sample of elderly people in "PNEI REVIEW" 1/2023, pp 106-122, DOI: 10.3280/PNEI2023-001007