Cognitive deficits are a significant feature of many psychiatric and neurological disorders, severely impacting daily functioning and quality of life. Cognitive Remediation (CR) has become an effective therapeutic approach aimed at improving cognitive impairments in a variety of conditions. Numerous studies have consistently shown that CR leads to significant improvements in cognitive performance, especially when integrated with psychosocial interventions. These interventions have been linked to better outcomes in areas such as employment, social interaction, and daily living skills. The digitalization of CR programs has brought important advancements, enhancing accessibility and engagement through personalized, homebased interventions that provide real-time feedback. While some challenges remain, particularly in ensuring the transfer of cognitive improvements to real-world contexts, the overall evidence supports the effectiveness of computerized CR in enhancing both cognitive and functional outcomes. Future research should aim to standardize outcome measures and further explore how to optimize CR’s integration into comprehensive treatment plans, ensuring long-term benefits.