Indoor pollution is an increasingly relevant yet socially underestimated public health issue, involving everyday environments traditionally associated with safety and protection. Chemical, biological, and physical hazards interact with housing conditions and social practices, producing cumulative exposures that remain largely invisible and unevenly distributed. Drawing on an integrated perspective, the article combines an examination of major indoor risk sources with a sociological analysis of the social invisibility of exposure, risk perception, and the individualization of responsibility, showing how inequalities shape both vulnerability and responses to risk. The paper argues that the One Health approach should be understood not only as interdisciplinary cooperation but as a transformative framework capable of reconnecting biological, environmental, and social dimensions of health. Conceptualizing indoor environments as everyday ecosystems, the article calls for a shift from individualized and downstream responses toward preventive and intersectorial governance addressing structural determinants of exposure.