The mood microbes

Journal title PNEI REVIEW
Author/s Rita Tancredi, Paola Di Persia, Accursio Gennaro
Publishing Year 2019 Issue 2019/2 Language Italian
Pages 10 P. 103-112 File size 112 KB
DOI 10.3280/PNEI2019-002010
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The aim of this review is to summarize the current knowledge concerning the mutual influence between the enteric microbial species and the health of the human host. The communities of intestinal microorganisms fulfil functions ranging from synthetic and metabolic activity to the maturation of the immune system and regulation of mood and behaviour; moreover, through psychobiotic interventions and germ-free studies, it has been highlighted the potentiality of the gastro-intestinal microbiota (GI) to modulate the bidirectional communication between the central nervous system (CNS) and the enteric nervous system (ENS), mediated by neuronal, endocrine and immunological pathways and responsible for individual homeostasis. The critical components of the microbiota-gut-brain axis and the possible clinical-pathological implications deriving from deficits in the aforementioned interaction will therefore be discussed, outlining how therapies addressed to normal microflora could be effective preven tion and treatment strategies not only for metabolic and chronic inflammatory diseases, but also for neuropsychiatric disorders such as anxiety and depression.

Keywords: Microbiota-gut-brain axis, Gut dysbiosis, Neurotransmitters, Stress, Major depressive disorder, Psychobiotic therapies

  1. Stuart A.L., Hayley A.C., Byrne M.L. and Maes M. (2013). So depression is an inflammatory disease, but where does the inflammation come from?. BMC Med., 11: 200. DOI: 10.1186/1741-7015-11-20
  2. Bilbo S.D. and Schwarz J.M. (2012). The immune system and developmental programming of brain and behavior. Front. Neuroendocrinol., 33: 267-286.
  3. Bottaccioli A.G., Bottaccioli F. and Minelli A. (2019). Stress and the psyche-brainimmune network in psychiatric diseases based on psychoneuroendocrineimmunology: a concise review. Ann. N.Y. Acad. Sci., 1437(1): 31-42.
  4. Capurso L. (2016). Il microbiota intestinale. Recenti Prog. Med., 107:257-266. DOI: 10.1701/2296.2468
  5. Collins M.D. and Gibson G.R. (1999). Probiotics, prebiotics, and synbiotics: approaches for modulating the microbial ecology of the gut. Am. J. Clin. Nutr., 69: 1052S-1057S.
  6. Cryan J.F. and O’Mahony S.M. (2011). The microbiome-gut-brain axis: from bowel to behavior. Neurogastroenterol. Motil., 23:187-192.
  7. Dethlefsen L., McFall-Ngai M. and Relman D.A. (2007). An ecological and evolutionary perspective on human-microbe mutualism and disease. Nature, 449: 811-8.
  8. Evrensel A. and Ceylan M.E. (2015). The Gut-Brain Axis: The Missing Link in Depression. Clin. Psychopharmacol. Neurosci., 13(3): 239-244.
  9. FAO/WHO (2001). Health and Nutritional Properties of Probiotics in Food including Powder Milk with Live Lactic Acid Bacteria. -- Testo disponibile al sito: http://www.fao.org/tempref/docrep/fao/meeting/009/y6398e.pdf, visitato il 14/06/2019.
  10. Foster J.A., Rinaman L. and Cryan J.F. (2017). Stress & the gut-brain axis: Regulation by the microbiome. Neurobiol. Stress, 7: 124-136.
  11. Gibson G.R., Scott K.P., Rastall R.A., Tuohy K.M., Hotchkiss A., Dubert-Ferrandon A., Gareau M., Murphy E.F.,Saulnier D., Loh G., Macfarlane S., Delzenne N., Ringel Y., Kozianowski G., Dickmann R., Lenoir-Wijnkoop I.,Walker C. and Buddington R. (2010). Dietary prebiotics:current status and new definition. Food Sci. Technol.Bull. Funct. Foods, 7: 1-19. DOI: 10.1616/1476-2137.1588
  12. Grochowska M., Wojnar M. and Radkowski M. (2018). The gut microbiota in neuropsychiatric disorders. Acta Neurobiol. Exp., 78: 69-81.
  13. Jiang H., Ling Z., Zhang Y., Mao H., Ma Z., Yin Y., Wang W., Tang W., Tan Z., Shi J., Li L. and Ruan B. (2015). Altered fecal microbiota composition in patients with major depressive disorder. Brain Behav. Immun., 48: 186-194.
  14. Licht T.R., Ebersbach T. and Frøkiær H. (2012). Prebiotics for prevention of gut infections. Trends Food Sci. Technol., 23: 70-82.
  15. Logan A.C. and Katzman M.(2005). Major depressive disorder: probiotics may be an adjuvant therapy. Med. Hypotheses, 64: 533-538.
  16. Lozupone C.A., Stornbaugh J.I., Gordon J.I., Jansson J.K. and Knight R. (2012). Diversity, stability and resilience of the human gut microbiota. Nature, 489: 220-230.
  17. Lyte M. and Cryan J.F., eds. (2014). Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease. New York: Springer-Verlag.
  18. Marangoni F. e Poli A. (2017). Microbiota intestinale, Probiotici e Salute Umana. Pisa: Pacini Editore Srl. -- Testo diponibile al sito: https://www.pacinimedicina.it/wp-content/uploads/probiotici_w.pdf, visitato il 14/06/2019.
  19. Messaoudi M., Lalonde R., Violle N., Javelot H., Desor D., Nejdi A., Bisson J.F., Rougeot C., Pichelin M., Cazaubiel M. and Cazaubiel J.M. (2011a). Assessment of psychotropic-like properties of a probiotic formulation Lactbacillus helveticus R0052 and Bifidobacterium longum R0175 in rats and human subjects. Br. J. Nutr., 105: 755-764. DOI: 10.1017/S000711451000431
  20. Messaoudi M., Violle N., Bisson J.F., Desor D., Javelot H. and Rougeot C. (2011b). Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers. Gut Microbes, 2: 256-261.
  21. Moschetta A. (2018). Il tuo metabolismo. L’utilità della dieta nella prevenzione e cura del cancro. Milano: Mondadori.
  22. Rieder R., Wisniewski P.J., Alderman B.L. and Campbell S.C. (2017). Microbes and mental health: A review. Brain Behav. Immun., 66: 9-17.
  23. Schwiertz A., ed. (2016). Microbiota of the Human Body. Implications in Health and Disease. Cham: Springer International Publishing Switzerland.
  24. Sherwin E., Dinan T.G. and Cryan J.F. (2017). Recent developments in understanding the role of the gut microbiota in brain health and disease. Ann. N.Y. Acad. Sci., 1420: 5-25.
  25. Tillisch K., Labus J.S., Ebrat B., Stains J., Naliboff B.D., Guyonnet D., Legrain-Raspaud S., Trotin B. and Mayer E.A. (2012). Modulation of the brain-gut axis after 4-week intervention with a probiotic fermented dairy product. Gastroenterol., 142(5 S1): S-115. DOI: 10.1016/S0016-5085(12)60435-

Rita Tancredi, Paola Di Persia, Accursio Gennaro, I microbi dell’umore in "PNEI REVIEW" 2/2019, pp 103-112, DOI: 10.3280/PNEI2019-002010