Journal title PNEI REVIEW
Author/s Massimo Agnoletti, Alessio Fasano
Online First 2/25/2025 Issue 2025/1
Language English Pages 10 P. 1-10 File size 0 KB
DOI 10.3280/pnei2025oa19441
DOI is like a bar code for intellectual property: to have more infomation
click here
FrancoAngeli is member of Publishers International Linking Association, Inc (PILA), a not-for-profit association which run the CrossRef service enabling links to and from online scholarly content.
The science of the microbiota, by revealing the complexity of interactions between the world of microorganisms that colonize us and that of human cells, represents the dawn of a new paradigm in biomedical and psychological sciences. It allows for a more complex yet more promising perspective on human health and disease compared to previous approaches. Scientific literature has now identified specific lifestyle-related factors (nutrition, environmental physicalchemical quality, psychological well-being, etc.) that significantly influence the composition of the microbiota. This paper introduces the concept of the “funnel effect” of the microbiota to describe the convergent and partially independent nature of these factors (nutrition, physical activity, psychological well-being, sleep quality, social support, environmental physical-chemical quality, circadian rhythms) on the composition of the intestinal microbiota, thereby impacting the overall health of the human organism. The “funnel effect” of the microbiota has some highly relevant clinical implications, emphasizing the need for an integrated psycho-neuro-endocrineimmunological approach, in contrast to the highly specialized and molecularly focused approach that is currently widely adopted.
Massimo Agnoletti, Alessio Fasano, The microbiota’s funnel effect: How multiple factors independently converge in changing the microbiota in "PNEI REVIEW" 1/2025, pp 1-10, DOI: 10.3280/pnei2025oa19441