Impact of malnutrition ad sarcopenia on mental health and quality of life in liver transplantation candidates

Journal title RIVISTA SPERIMENTALE DI FRENIATRIA
Author/s Serena Bursi
Publishing Year 2022 Issue 2022/2
Language Italian Pages 14 P. 95-108 File size 172 KB
DOI
DOI is like a bar code for intellectual property: to have more infomation click here

Below, you can see the article first page

If you want to buy this article in PDF format, you can do it, following the instructions to buy download credits

Article preview

FrancoAngeli is member of Publishers International Linking Association, Inc (PILA), a not-for-profit association which run the CrossRef service enabling links to and from online scholarly content.

Candidates to liver transplantation and patients already transplanted are considered by many authors as "frail patients". Frailty places the patient at greater risk of complications, hospitalizations and loss of autonomy, with serious repercussions on the quality of life and psychophysical well-being. In recent years, more and more evidence has emerged on the role of malnutrition and sarcopenia as risk factors for psychiatric comorbidity in the candidate patient or undergoing liver transplantation, as they aggravate the condition of fragility. Patients with alcoholic liver disease are among those at greatest risk of malnutrition and with situations of greater bio-psycho-social complexity, both for the underlying chronic disease and for psychiatric comorbidities and associated social variables. Prevention and treatment of malnutrition in these patients greatly impact on disease and mortality outcomes, but also on mental health and on the degree of dependence of the patient on his caregivers as evidenced by several studies. The purpose of this review is to frame the role of malnutrition and sarcopenia as risk factors for frailty and mental distress in this category of patients.

Keywords: Liver transplant, psychopathology, depression, anxiety, malnutrition, sarcopenia.

  1. EASL Clinical Practice Guidelines on nutrition in chronic liver disease. J Hepatol. gennaio 2019; 70(1): 172-93.
  2. Chang KV, Hsu TH, Wu WT, Huang KC, Han DS. Is sarcopenia associated with depression? A systematic review and meta-analysis of observational studies. Age Ageing. 1 settembre 2017; 46(5): 738-46.
  3. Plauth M, Bernal W, Dasarathy S, Merli M, Plank LD, Schütz T, et al. ESPEN guideline on clinical nutrition in liver disease. Clin Nutr. aprile 2019; 38(2): 485-521.
  4. Cederholm T, Barazzoni R, Austin P, Ballmer P, Biolo G, Bischoff SC, et al. ESPEN guidelines on definitions and terminology of clinical nutrition. Clin Nutr. febbraio 2017; 36(1): 49-64.
  5. Beurel E, Toups M, Nemeroff CB. The Bidirectional Relationship of Depression and Inflammation: Double Trouble. Neuron. 22 luglio 2020;107(2): 234-56.
  6. Cederholm T, Jensen GL, Correia MITD, Gonzalez MC, Fukushima R, Higashiguchi T, et al. GLIM criteria for the diagnosis of malnutrition - A consensus report from the global clinical nutrition community. Clin Nutr Edinb Scotl. 2019; 38(1): 1-9.
  7. Kelly DM, Bennett R, Brown N, McCoy J, Boerner D, Yu C, et al. Predicting the discharge status after liver transplantation at a single center: A new approach for a new era. Liver Transpl. 2012; 18(7): 796-802.
  8. Gamberale R, D’Orlando C, Brunelli S, Meneveri R, Mazzola P, Foti G, et al. Study protocol: understanding the pathophysiologic mechanisms underlying delirium in older people undergoing hip fracture surgery. BMC Geriatr. 4 novembre 2021; 21: 633.
  9. Bellelli G, Zambon A, Volpato S, Abete P, Bianchi L, Bo M, et al. The
  10. association between delirium and sarcopenia in older adult patients admitted to acute geriatrics units: Results from the GLISTEN multicenter observational study. Clin Nutr Edinb Scotl. ottobre 2018;37(5): 1498-504.
  11. Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 01 2019; 48(1): 16-31.
  12. Jindal A, Jagdish RK. Sarcopenia: Ammonia metabolism and hepatic encephalopathy. Clin Mol Hepatol. settembre 2019; 25(3): 270-9.
  13. Duarte-Rojo A, Ruiz-Margáin A, Montaño-Loza AJ, Macías-Rodríguez RU, Ferrando A, Kim WR. Exercise and physical activity for patients with end- stage liver disease: Improving functional status and sarcopenia while on the transplant waiting list. Liver Transpl. 2018; 24(1): 122-39.
  14. Stirnimann G, Ebadi M, Tandon P, Montano-Loza AJ. Should Sarcopenia Increase Priority for Transplant or Is It a Contraindication? Curr Gastroenterol Rep. 26 settembre 2018; 20(11): 50.
  15. West J, Gow PJ, Testro A, Chapman B, Sinclair M. Exercise physiology in cirrhosis and the potential benefits of exercise interventions: A review. J Gastroenterol Hepatol. 2021; 36(10): 2687-705.
  16. Kim WR, Therneau TM, Dickson ER, Evans RW. Preoperative predictors of resource utilization in liver transplantation. Clin Transpl. 1995; 315-22.
  17. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in Older Adults: Evidence for a Phenotype. J Gerontol A Biol Sci Med Sci. 1 marzo 2001; 56(3): M146-57.
  18. Moscara M, Mattei G, Ferrari S, Galeazzi GM. Why candidates for liver transplantation should be considered as frail patients. Minerva Gastroenterol Dietol [Internet]. aprile 2020 [citato 22 aprile 2022];66(1). -- Disponibile su: https://www.minervamedica.it/index2.php?show=R08Y2020N01A0084.
  19. Lai JC, Feng S, Terrault NA, Lizaola B, Hayssen H, Covinsky K. Frailty Predicts Wait-List Mortality in Liver Transplant Candidates. Am J Transplant Off J Am Soc Transplant Am Soc Transpl Surg. agosto 2014; 14(8): 1870-9.
  20. Kulkarni SS, Chen H, Josbeno DA, Schmotzer A, Hughes C, Humar A, et al. Gait Speed and Grip Strength Are Associated With Dropping Out of the Liver Transplant Waiting List. Transplant Proc. aprile 2019; 51(3): 794-7.
  21. Delibaş DH, Eşkut N, İlhan B, Erdoğan E, Top Kartı D, Yılmaz Küsbeci Ö, et al. Clarifying the relationship between sarcopenia and depression in geriatric outpatients. Aging Male. 1 gennaio 2021; 24(1): 29-36.
  22. Sieber CC. Malnutrition and sarcopenia. Aging Clin Exp Res. giugno 2019; 31(6): 793-8.
  23. Román E, Torrades MT, Nadal MJ, Cárdenas G, Nieto JC, Vidal S, et al. Randomized pilot study: effects of an exercise programme and leucine supplementation in patients with cirrhosis. Dig Dis Sci. agosto 2014; 59(8): 1966-75.
  24. Williams FR, Berzigotti A, Lord JM, Lai JC, Armstrong MJ. Review article: impact of exercise on physical frailty in patients with chronic liver disease. Aliment Pharmacol Ther. novembre 2019; 50(9): 988-1000.
  25. Testino Gianni, Balbinot Patrizia, Leone Silvia, Pellicano Rinaldo. Management of alcohol related liver disease in liver transplant candidate patients. Minerva Gastroenterol Dietol. settembre 2020; 66(3): 291-2.
  26. Paluska SA, Schwenk TL. Physical Activity and Mental Health. Sports Med. 1 marzo 2000; 29(3): 167-80.
  27. Deslandes A, Moraes H, Ferreira C, Veiga H, Silveira H, Mouta R, et al. Exercise and Mental Health: Many Reasons to Move. Neuropsychobiology. 2009; 59(4): 191-8.
  28. Friedli N, Stanga Z, Culkin A, Crook M, Laviano A, Sobotka L, et al. Management and prevention of refeeding syndrome in medical inpatients: An evidence-based and consensus-supported algorithm. Nutrition. 1 marzo 2018; 47: 13-20.
  29. Vilar-Gomez E, Martinez-Perez Y, Calzadilla-Bertot L, Torres-Gonzalez A,
  30. Gra-Oramas B, Gonzalez-Fabian L, et al. Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis. Gastroenterology. agosto 2015; 149(2): 367-378.e5.
  31. Pagadala M, Dasarathy S, Eghtesad B, McCullough AJ. Posttransplant metabolic syndrome: An epidemic waiting to happen. Liver Transpl. 2009; 15(12): 1662-70.
  32. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 16 gennaio 2002; 287(3): 356-9.
  33. Rozenberg D, Santa Mina D, Nourouzpour S, Camacho Perez E, Stewart BL, Wickerson L, et al. Feasibility of a Home-Based Exercise Program for Managing Posttransplant Metabolic Syndrome in Lung and Liver Transplant Recipients: Protocol for a Pilot Randomized Controlled Trial. JMIR Res Protoc. 23 marzo 2022; 11(3): e35700.
  34. Zimbrean PC, Gan G, Deng Y, Emre S. Body Image in Liver Transplantation Recipients. Liver Transpl. 2019; 25(5): 712-23.

Serena Bursi, Influenza di malnutrizione e sarcopenia sulla salute mentale e sulla qualità di vita dei pazienti candidati a trapianto epatico in "RIVISTA SPERIMENTALE DI FRENIATRIA" 2/2022, pp 95-108, DOI: