Epigenetic modifi cations. An aspect long ignored in studies aimed at evaluating gene-environment interactions in Alzheimer’s disease

Journal title PNEI REVIEW
Author/s Fabio Coppedè
Publishing Year 2023 Issue 2023/1
Language Italian Pages 15 P. 53-67 File size 1124 KB
DOI 10.3280/PNEI2023-001004
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Alzheimer’s disease (AD) is mainly sporadic and likely resulting from complex in- teractions between genetic and environmental factors. Many of the potential envi- ronmental risk factors for AD are capable of inducing epigenetic modifications, an aspect long ignored in studies aimed at evaluating gene-environment interactions in this disease. In this article the author describes the genetic and environmental risk factors for the disease and how their interactions could in part be mediated by epigenetic mechanisms.

Keywords: Disease, Epigenetics, Susceptibility Genes, Environmental Factors, DNA Methylation, Gene-Environment Interactions

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Fabio Coppedè, Le modifi cazioni epigenetiche. Un aspetto a lungo ignorato negli studi atti a valutare le interazioni geni-ambiente nella malattia di Alzheimer in "PNEI REVIEW" 1/2023, pp 53-67, DOI: 10.3280/PNEI2023-001004