G-Lymphatic System In The Brain: Instructions For Use

Journal title PNEI REVIEW
Author/s Paolo Zamboni, Attilio Cavezzi
Publishing Year 2020 Issue 2020/2 Language Italian
Pages 14 P. 41-54 File size 200 KB
DOI 10.3280/PNEI2020-002005
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The role of brain drainage in the pathogenesis of neuroinflammatory/neurodegenerative diseases is largely unknown. Recently, in the central nervous system (CNS) the so-called g-lymphatic system (nomenclature derived from the fundamental role of the glia) has been identified. It allows the drainage of the cerebrospinal fluid, peptides and toxins respectively into the venous system and the meningeal and deep cervical lymphatics, as demonstrated in the last few years. Such recent discoveries now allow to hypothesize a crucial role of the hemo-lymphatic drainage system of the CNS in the process of neuroinflammation and/or neurodegeneration. This article reports the most current knowledge that links the pathophysiology of the g-lymphatic system of the CNS to neurodegenerative diseases (Parkinson’s, Alzheimer’s, multiple sclerosis, etc.). Finally, the possibilities and limits of some therapeutic options, from a Pnei point of view, aimed at improving the flow of the cerebro-spinal lymph are exposed.

Keywords: G-lymphatic system, Cerebrospinal flu

Paolo Zamboni, Attilio Cavezzi, Il sistema g-linfatico cerebrale: istruzioni per l’uso in "PNEI REVIEW" 2/2020, pp 41-54, DOI: 10.3280/PNEI2020-002005